Gadolinium attenuates exercise pressor reflex in cats

被引:79
作者
Hayes, SG
Kaufman, MP
机构
[1] Univ Calif Davis, Dept Internal Med, Div Cardiovasc Med, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Human Physiol, Davis, CA 95616 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2001年 / 280卷 / 05期
关键词
group III and IV muscle afferents; contraction; tendon stretch; capsaicin; autonomic nervous system;
D O I
10.1152/ajpheart.2001.280.5.H2153
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The exercise pressor reflex, which arises from the contraction-induced stimulation of group III and IV muscle afferents, is widely believed to be evoked by metabolic stimuli signaling a mismatch between blood/oxygen demand and supply in the working muscles. Nevertheless, mechanical stimuli may also play a role in evoking the exercise pressor reflex. To determine this role, we examined the effect of gadolinium, which blocks mechanosensitive channels, on the exercise pressor reflex in both decerebrate and alpha -chloralose-anesthetized cats. We found that gadolinium (10 mM; 1 ml) injected into the femoral artery significantly attenuated the reflex pressor responses to static contraction of the triceps surae muscles and to stretch of the calcaneal (Achilles) tendon. In contrast, gadolinium had no effect on the reflex pressor response to femoral arterial injection of capsaicin (5 mug). In addition, gadolinium significantly attenuated the responses of group III muscle afferents, many of which are mechanically sensitive, to both static contraction and to tendon stretch. Gadolinium, however, had no effect on the responses of group IV muscle afferents, many of which are metabolically sensitive, to either static contraction or to capsaicin injection. We conclude that mechanical stimuli arising in contracting skeletal muscles contribute to the elicitation of the exercise pressor reflex.
引用
收藏
页码:H2153 / H2161
页数:9
相关论文
共 39 条
[1]   Effect of arterial occlusion on responses of group III and IV afferents to dynamic exercise [J].
Adreani, CM ;
Kaufman, MP .
JOURNAL OF APPLIED PHYSIOLOGY, 1998, 84 (06) :1827-1833
[2]  
ADREANI CM, J APPL PHYSL, V86, P1811
[3]   GADOLINIUM AND MECHANOTRANSDUCTION OF RAT AORTIC BARORECEPTORS [J].
ANDRESEN, MC ;
YANG, MY .
AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 262 (05) :H1415-H1421
[4]  
CRAYTON SC, 1981, AM J PHYSIOL-HEART C, V240, pHO15
[5]   BLOCKADE OF THE PRESSOR-RESPONSE TO MUSCLE ISCHEMIA BY SENSORY NERVE BLOCK IN MAN [J].
FREUND, PR ;
ROWELL, LB ;
MURPHY, TM ;
HOBBS, SF ;
BUTLER, SH .
AMERICAN JOURNAL OF PHYSIOLOGY, 1979, 237 (04) :H433-H439
[6]   HEMODYNAMIC-EFFECTS OF MEDICAL ANTI-SHOCK TROUSERS (MAST GARMENT) [J].
GAFFNEY, FA ;
THAL, ER ;
TAYLOR, WF ;
BASTIAN, BC ;
WEIGELT, JA ;
ATKINS, JM ;
BLOMQVIST, CG .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1981, 21 (11) :931-937
[7]   GADOLINIUM INHIBITS MECHANOELECTRICAL TRANSDUCTION IN RABBIT CAROTID BARORECEPTORS - IMPLICATION OF STRETCH-ACTIVATED CHANNELS [J].
HAJDUCZOK, G ;
CHAPLEAU, MW ;
FERLIC, RJ ;
MAO, HZ ;
ABBOUD, FM .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (06) :2392-2396
[8]  
Hamill OP, 1996, PHARMACOL REV, V48, P231
[9]   CARDIAC ACCELERATION IN MAN ELICITED BY A MUSCLE-HEART REFLEX [J].
HOLLANDER, AP ;
BOUMAN, LN .
JOURNAL OF APPLIED PHYSIOLOGY, 1975, 38 (02) :272-278
[10]   PRESSOR REFLEX EVOKED BY MUSCULAR-CONTRACTION - CONTRIBUTIONS BY NEURAXIS LEVELS [J].
IWAMOTO, GA ;
WALDROP, TG ;
KAUFMAN, MP ;
BOTTERMAN, BR ;
RYBICKI, KJ ;
MITCHELL, JH .
JOURNAL OF APPLIED PHYSIOLOGY, 1985, 59 (02) :459-467