Developmental biology -: Casting an eye over cyclopia

被引：14

作者：

Blader, P ^{[1
]}

Strähle, U ^{[1
]}

机构：

[1] ULP, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch, France

来源：

NATURE | 1998年 / 395卷 / 6698期

关键词：

D O I：

10.1038/25836

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cyclopia — the development of a single, central eye — occurs because of a lack of, or defect in, development of the ventral (fore) brain. Three groups have studied this developmental pathway in the zebrafish, and have identified two of the genes involved. Fish that lack the cyclops (cyc) and squint (sqt) genes are cyclopic. Moreover, the authors have found that Cyclops belongs to the transforming growth factor-β family of proteins.

引用

页码：112 / 113

页数：2

共 13 条

[1] Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function [J].

Chiang, C ;

Ying, LTT ;

Lee, E ;

Young, KE ;

Corden, JL ;

Westphal, H ;

Beachy, PA .

NATURE, 1996, 383 (6599) :407-413

[2] Zebrafish organizer development and germ-layer formation require nodal-related signals [J].

Feldman, B ;

Gates, MA ;

Egan, ES ;

Dougan, ST ;

Rennebeck, G ;

Sirotkin, HI ;

Schier, AF ;

Talbot, WS .

NATURE, 1998, 395 (6698) :181-185

[3] THE CYCLOPS MUTATION BLOCKS SPECIFICATION OF THE FLOOR PLATE OF THE ZEBRAFISH CENTRAL-NERVOUS-SYSTEM [J].

HATTA, K ;

KIMMEL, CB ;

HO, RK ;

WALKER, C .

NATURE, 1991, 350 (6316) :339-341

[4] The function of silberblick in the positioning of the eye anlage in the zebrafish embryo [J].

Heisenberg, CP ;

NussleinVolhard, C .

DEVELOPMENTAL BIOLOGY, 1997, 184 (01) :85-94

[5] Smad2 role in mesoderm formation, left-right patterning and craniofacial development [J].

Nomura, M ;

Li, E .

NATURE, 1998, 393 (6687) :786-790

[6] Vertebrate genome evolution and the zebrafish gene map [J].

Postlethwait, JH ;

Yan, YL ;

Gates, MA ;

Horne, S ;

Amores, A ;

Brownlie, A ;

Donovan, A ;

Egan, ES ;

Force, A ;

Gong, ZY ;

Goutel, C ;

Fritz, A ;

Kelsh, R ;

Knapik, E ;

Liao, E ;

Paw, B ;

Ransom, D ;

Singer, A ;

Thomson, M ;

Abduljabbar, TS ;

Yelick, P ;

Beier, D ;

Joly, JS ;

Larhammar, D ;

Rosa, F ;

Westerfield, M ;

Zon, LI ;

Johnson, SL ;

Talbot, WS .

NATURE GENETICS, 1998, 18 (04) :345-349

[7] cyclops encodes a nodal-related factor involved in midline signaling [J].

Rebagliati, MR ;

Toyama, R ;

Haffter, P ;

Dawid, IB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :9932-9937

[8] Zebrafish nodal-related genes are implicated in axial patterning and establishing left-right asymmetry [J].

Rebagliati, MR ;

Toyama, R ;

Fricke, C ;

Haffter, P ;

Dawid, IB .

DEVELOPMENTAL BIOLOGY, 1998, 199 (02) :261-272

[9] Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling [J].

Sampath, K ;

Rubinstein, AL ;

Cheng, AHS ;

Liang, JO ;

Fekany, K ;

Solnica-Krezel, L ;

Korzh, V ;

Halpern, ME ;

Wright, CVE .

NATURE, 1998, 395 (6698) :185-189

[10] Diversity and pattern in the developing spinal cord [J].

Tanabe, Y ;

Jessell, TM .

SCIENCE, 1996, 274 (5290) :1115-1123

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