Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report of a Task Force at the 13th International Congress on Antiphospholipid Antibodies

被引：346

作者：

Ruiz-Irastorza, G. ^{[1
]}

Cuadrado, M. J. ^{[2
]}

Ruiz-Arruza, I. ^{[1
]}

Brey, R. ^{[3
]}

Crowther, M. ^{[4
]}

Derksen, R. ^{[5
]}

Erkan, D. ^{[6
]}

Krilis, S. ^{[7
]}

Machin, S. ^{[8
]}

Pengo, V. ^{[9
]}

Pierangeli, S. ^{[10
]}

Tektonidou, M. ^{[11
]}

Khamashta, M. ^{[2
]}

机构：

[1] Univ Basque Country, Hosp Cruces, Dept Internal Med, Autoimmune Dis Res Unit, Baracaldo, Spain

[2] Kings Coll London, Rayne Inst, Lupus Res Unit, Guys Kings & St Thomas Sch Med, London WC2R 2LS, England

[3] Univ Texas Hlth Sci Ctr San Antonio, Sch Med, Dept Neurol, San Antonio, TX USA

[4] McMaster Univ, Div Hematol & Thromboembolism, Hamilton, ON L8S 4L8, Canada

[5] Univ Med Ctr, Dept Rheumatol & Clin Immunol, Utrecht, Netherlands

[6] Cornell Univ, Hosp Special Surg, Barbara Volcker Ctr Women & Rheumat Dis, Weill Med Coll, New York, NY 10021 USA

[7] Univ New S Wales, St George Hosp, Dept Immunol Allergy & Infect Dis, Sydney, NSW 2052, Australia

[8] UCL, Dept Haematol, London, England

[9] Univ Hosp, Padua, Italy

[10] Univ Texas Med Branch, Antiphospholipid Standardizat Lab, Div Rheumatol, Dept Internal Med, Galveston, TX USA

[11] Natl Tech Univ Athens, Sch Med, Dept Internal Med 1, Athens, Greece

来源：

LUPUS | 2011年 / 20卷 / 02期

关键词：

anticardiolipin; antiphospholipid; aspirin; hydroxychloroquine; lupus anticoagulant; prevention; stroke; thrombosis; warfarin; SYSTEMIC-LUPUS-ERYTHEMATOSUS; RISK-FACTORS; ANTICARDIOLIPIN ANTIBODIES; ISCHEMIC-STROKE; VENOUS THROMBOEMBOLISM; ANTITHROMBOTIC THERAPY; ANTICOAGULANT-THERAPY; PHOSPHOLIPID SYNDROME; RECURRENT THROMBOSIS; CLINICAL-OUTCOMES;

D O I：

10.1177/0961203310395803

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid antibodies: lupus anticoagulant, anticardiolipin antibodies and/or anti-beta 2-glycoprotein I antibodies in medium to high titers. The management of thrombosis in patients with APS is a subject of controversy. This set of recommendations is the result of an effort to produce guidelines for therapy within a group of specialist physicians in Cardiology, Neurology, Hematology, Rheumatology and Internal Medicine, with a clinical and research focus on APS. Lupus (2011) 20, 206-218.

引用

页码：206 / 218

页数：13

共 75 条

[1] Antithrombotic and thrombolytic therapy for ischemic stroke [J].

Albers, Gregory W. ;

Amarenco, Pierre ;

Easton, J. Donald ;

Sacco, Ralph L. ;

Teal, Philip .

CHEST, 2008, 133 (06) :630S-669S

[2] Classification of Stroke Subtypes [J].

Amarenco, P. ;

Bogousslavsky, J. ;

Caplan, L. R. ;

Donnan, G. A. ;

Hennerici, M. G. .

CEREBROVASCULAR DISEASES, 2009, 27 (05) :493-501

[3] A computerized algorithm for etiologic classification of ischemic stroke - The causative classification of stroke system [J].

Ay, Hakan ;

Benner, Thomas ;

Arsava, E. Murat ;

Furie, Karen L. ;

Singhal, Aneesh B. ;

Jensen, Matt B. ;

Ayata, Cenk ;

Towfighi, Amytis ;

Smith, Eric E. ;

Chong, Ji Y. ;

Koroshetz, Walter J. ;

Sorensen, A. Gregory .

STROKE, 2007, 38 (11) :2979-2984

[4] Diagnostic testing for coagulopathies in patients with ischemic stroke [J].

Bushnell, CD ;

Goldstein, LB .

STROKE, 2000, 31 (12) :3067-3078

[5] Antiphospholipid syndrome -: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients [J].

Cervera, R ;

Piette, JC ;

Font, J ;

Khamashta, MA ;

Cervera, R ;

Piette, JC ;

Font, J ;

Khamashta, MA ;

Shoenfeld, Y ;

Camps, MT ;

Jacobsen, S ;

Lakos, G ;

Tincani, A ;

Kontopoulou-Griva, I ;

Galeazzi, M ;

Meroni, PL ;

Derksen, RHWM ;

de Groot, PG ;

Gromnica-Ihle, E ;

Baleva, M ;

Mosca, M ;

Bombardieri, S ;

Houssiau, F ;

Gris, JC ;

Quéré, I ;

Hachulla, E ;

Vasconcelos, C ;

Roch, B ;

Fernández-Nebro, A ;

Boffa, MC ;

Hughes, GRV ;

Ingelmo, M .

ARTHRITIS AND RHEUMATISM, 2002, 46 (04) :1019-1027

[6] Morbidity and mortality in systemic lupus erythematosus during a 5-year period -: A multicenter prospective study of 1,000 patients [J].

Cervera, R ;

Khamashta, MA ;

Font, J ;

Sebastiani, GD ;

Gil, A ;

Lavilla, P ;

Aydintug, AO ;

Jedryka-Góral, A ;

de Ramón, E ;

Fernández-Nebro, A ;

Galeazzi, M ;

Haga, HJ ;

Mathieu, A ;

Houssiau, F ;

Ruiz-Irastorza, G ;

Ingelmo, M ;

Hughes, GRV .

MEDICINE, 1999, 78 (03) :167-175

[7] Morbidity and mortality in the antiphospholipid syndrome during a 5-year period: a multicentre prospective study of 1000 patients [J].

Cervera, R. ;

Khamashta, M. A. ;

Shoenfeld, Y. ;

Camps, M. T. ;

Jacobsen, S. ;

Kiss, E. ;

Zeher, M. M. ;

Tincani, A. ;

Kontopoulou-Griva, I. ;

Galeazzi, M. ;

Bellisai, F. ;

Meroni, P. L. ;

Derksen, R. H. W. M. ;

de Groot, P. G. ;

Gromnica-Ihle, E. ;

Baleva, M. ;

Mosca, M. ;

Bombardieri, S. ;

Houssiau, F. ;

Gris, J-C ;

Quere, I. ;

Hachulla, E. ;

Vasconcelos, C. ;

Roch, B. ;

Fernandez-Nebro, A. ;

Piette, J-C ;

Espinosa, G. ;

Bucciarelli, S. ;

Pisoni, C. N. ;

Bertolaccini, M. L. ;

Boffa, M-C ;

Hughes, G. R. V. .

ANNALS OF THE RHEUMATIC DISEASES, 2009, 68 (09) :1428-1432

[8] Anticoagulation treatment withdrawal in primary antiphospholipid syndrome when anticardiolipin antibodies become negative [J].

Criado-Garcia, J. ;

Fernandez-Puebla, R. A. ;

Jimenez, L. Lopez ;

Velasco, F. ;

Santamaria, M. ;

Blanco-Molina, A. .

REVISTA CLINICA ESPANOLA, 2008, 208 (03) :135-137

[9] A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome [J].

Crowther, MA ;

Ginsberg, JS ;

Julian, J ;

Denburg, J ;

Hirsh, J ;

Douketis, J ;

Laskin, C ;

Fortin, P ;

Anderson, D ;

Kearon, C ;

Clarke, A ;

Geerts, W ;

Forgie, M ;

Green, D ;

Costantini, L ;

Yacura, W ;

Wilson, S ;

Gent, M ;

Kovacs, MJ .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (12) :1133-1138

[10] Determinants of Risk for Venous and Arterial Thrombosis in Primary Antiphospholipid Syndrome and in Antiphospholipid Syndrome with Systemic Lupus Erythematosus [J].

Danowski, Adriana ;

Leitao de Azevedo, Mario Newton ;

de Souza Papi, Jose Angelo ;

Petri, Michelle .

JOURNAL OF RHEUMATOLOGY, 2009, 36 (06) :1195-1199

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