Alterations in the activities of cerebral antioxidant enzymes of rat are related to aging

被引：39

作者：

Sahoo, A

Chainy, GBN ^{[1
]}

机构：

[1] SVM Coll, Dept Zool, Jagatsinghpur 754103, Orissa, India

[2] Utkal Univ, Dept Zool, Biochem Unit, Bhubaneswar 751004, Orissa, India

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 1997年 / 15卷 / 08期

关键词：

oxidative stress; lipid peroxidation; antioxidant enzymes; glutathione; ascorbic acid; brain aging;

D O I：

10.1016/S0736-5748(97)00049-X

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Developmental profiles of antioxidant enzymes and lipid peroxidation were investigated in rat cerebral hemisphere from birth to 600 days of age. Lipid peroxidation level decreased in the crude homogenate from birth until 15 days and, thereafter increased gradually up to 600 days. However, susceptibility of sub-cellular fractions to lipid peroxidation displayed an increasing trend with increasing age. Superoxide dismutase activity decreased gradually with age, whereas activities of catalase, glutathione peroxidase and glutathione reductase exhibited an elevation up to 90 days followed by either a stagnancy or diminution in the later life. No linearity was observed in the contents of glutathione, ascorbic acid and H2O2 in the tissue. The results suggest that free radicals could be the causative agents of the aging process in which antioxidant enzymes have a definite regulatory contribution. (C) 1997 ISDN. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：939 / 948

页数：10

共 43 条

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