Polymorphism - Integrated approach from high-throughput screening to crystallization optimization

被引：51

作者：

Hilfiker, R ^{[1
]}

Berghausen, J ^{[1
]}

Blatter, F ^{[1
]}

Burkhard, A ^{[1
]}

De Paul, SM ^{[1
]}

Freiermuth, B ^{[1
]}

Geoffroy, A ^{[1
]}

Hofmeier, U ^{[1
]}

Marcolli, C ^{[1
]}

Siebenhaar, B ^{[1
]}

Szelagiewicz, M ^{[1
]}

Vit, A ^{[1
]}

von Raumer, M ^{[1
]}

机构：

[1] Solvias AG, CH-4002 Basel, Switzerland

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2003年 / 73卷 / 02期

关键词：

carbamazepine; crystallization; high-throughput; polymorphism; screening;

D O I：

10.1023/A:1025409608944

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Crystal structure (polymorphism) as well as crystal shape (morphology) and size have a huge practical and commercial impact on active substances all the way from research to manufacture of the final product. For an optimal development process, it is important to have an integrated approach to these issues ranging from a systematic polymorphism screening to a controlled scale-up of the crystallization process. The polymorphism program has to be tailored according to the development stage. Particularly suitable for an early development stage is a high-throughput polymorphism screening, which is the basis for a more thorough investigation if the product proceeds further in development. Such a comprehensive polymorphism investigation involves further crystallization experiments and extensive physicochemical characterization of the various forms. In this article the high-throughput polymorphism screening method that we have developed is described. Using carbamazepine as an example, the power of this high-throughput polymorphism screening system is demonstrated. Not only were all published forms found, but also new forms were identified. In the second part of the article, important considerations for crystallization optimization are discussed, again using the example of carbamazepine.

引用

页码：429 / 440

页数：12

共 33 条

[1] Laser Raman spectroscopic analysis of polymorphic forms in microliter fluid volumes [J].