ApoE genotype-specific inhibition of apoptosis

被引：29

作者：

DeKroon, RM

Mihovilovic, M

Goodger, ZV

Robinette, JB

Sullivan, PM

Saunders, AM

Strittmatter, WJ ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Deane Lab, Div Neurol,Dep Med, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA

来源：

JOURNAL OF LIPID RESEARCH | 2003年 / 44卷 / 08期

关键词：

apolipoprotein E; high density lipoprotein; very low density lipoprotein; low density lipoprotein; atherosclerosis; endothelial cell;

D O I：

10.1194/jlr.M300097-JLR200

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Endothelial cell apoptosis can be initiated by withdrawing growth factors or serum, and is inhibited by HDL. Our results show that the total lipoprotein population from apolipoprotein E 4/4 (APOE4/4) sera is less anti-apoptotic than total lipoproteins from other APOE genotypes, as measured by caspase 3/7 activity. Moreover, APOE4/4 VLDL antagonizes the antiapoptotic activity of HDL by a mechanism requiring binding of apoE4 on VLDL particles to an LDL family receptor. jlr This ability of APOE4/4 VLDL to inhibit the antiapoptotic effects of HDL presents a potential mechanism by which the expression of several diseases, including atherosclerosis, is enhanced by the APOE4 genotype.

引用

页码：1566 / 1573

页数：8

共 31 条

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