Signaling pathways involved in lipopolysaccharide stimulation of prostaglandin production by rat hypothalamic astroglial cells

被引：8

作者：

Pistritto, G ^{[1
]}

Ciabattoni, G ^{[1
]}

Mancuso, C ^{[1
]}

Tringali, G ^{[1
]}

Preziosi, P ^{[1
]}

Navarra, P ^{[1
]}

机构：

[1] Catholic Univ, Sch Med, Inst Pharmacol, I-00168 Rome, Italy

来源：

JOURNAL OF ENDOTOXIN RESEARCH | 2000年 / 6卷 / 04期

关键词：

D O I：

10.1179/096805100101532199

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to investigate the mechanisms through which bacterial lipopolysaccharide (LPS) stimulates prostaglandin (PG) production in rat hypothalamic astroglial cells in vitro. The latter were treated with LPS alone or LPS plus antagonists of the interleukin-1 (IL-1) and nitric oxide (NO) pathways, and the subsequent changes in cyclooxygenase (COX) activity were monitored by measuring a COX end-product, prostaglandin E-2 (PGE(2)), released into the incubation medium. LPS produced a concentration-dependent increase in PGE, release from astroglia after 24 h incubation; experiments with selective antagonists showed that the increase in PGE(2) release induced by LPS may be, at least in part, mediated by IL-1 and NO.

引用

页码：307 / 311

页数：5

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