MR flow quantification using RACE: Clinical application to the carotid arteries

Real time MR now quantification was performed with real time acquisition and evaluation of motion (RACE) in a rigid phantom under steady flow conditions and in the common carotid arteries of 43 subjects aged 24-78 years. Hemodynamic information included the intraluminal velocity distribution during the complete cardiac cycle, the distensibility of the arterial wall, and age-dependent changes of the now curves, Systolic peak velocities of 51 +/- 33 cm/s and time-averaged volume flow rates of 4.3 +/- 2.0 ml/s were measured in healthy subjects. Flow rates below 3.0 ml/s and the observation of abnormal now patterns indicated stenoses greater than 70% in the region of the bifurcation (sensitivity: 83.3%; specificity: 93.7%; accuracy: 71.4%). Improvements may be achieved from a combination with MR angiography, providing both functional and morphologic vascular information noninvasively within one observer-independent examination, MR imaging, therefore, has a strong potential for the diagnosis of critical stenoses in symptomatic patients.