Mechanisms underlying phase lag between systemic arterial blood pressure and cerebral blood flow velocity

被引:26
作者
Kuo, TBJ
Chern, CM
Yang, CCH
Hsu, HY
Wong, WJ
Sheng, WY
Hu, HH [1 ]
机构
[1] Taipei Vet Gen Hosp, Sect Cerebrovasc Dis, Taipei 112, Taiwan
[2] Tzu Chi Univ, Inst Neurosci, Hualien, Peoples R China
[3] Tzu Chi Univ, Dept Physiol, Hualien, Peoples R China
[4] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan
关键词
cerebral autoregulation; cerebral blood flow; cross-correlation analysis; middle cerebral artery; transcranial Doppler sonography; transfer function analysis;
D O I
10.1159/000072564
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
To explore the mechanisms underlying the phase lag between oscillations in arterial blood pressure (ABP) and cerebral blood flow velocity (CBFV), ABP and CBFV signals were recorded noninvasively from normal volunteers who lay quietly in a supine position. Mean ABP (MAP) and CBFV (MFV) were Calculated beat-to-beat by means of integration. Cerebral vascular resistance (CVR) was calculated by dividing MAP with MFV. Frequency domain analysis of MAP, MFV and CVR signals revealed very-low frequency (VLF, 0.016-0.04 Hz), low-frequency (LF, 0.04-0.15 Hz), and high-frequency (HF, 0.15-0.4 Hz) components. The transfer phase of MAP-CVR coupling in the LF and HF range was frequency-dependent, which is equivalent to a time delay of 2 s. However, the transfer phase differed in the CVR-MFV coupling in that the phase was distributed around 180degrees across the LF and HF ranges. Cross-correlation analysis revealed a positive relationship between MAP-CVR coupling, with MAP leading by 2 s, and a negative relationship between CVR-MFV coupling, with CVR leading by 0.3 s. We concluded that the phase lag between oscillations in ABP and CBFV was chiefly contributed to by the starting latency of cerebral autoregulation (i.e. cerebral vasomotion, revealed by MAP-CVR coupling). Moreover, the negative correlation of the CVR-MFV coupling could offer a different explanation for the physiologic significance of the phase lead of CBFV-ABP oscillations. Copyright (C) 2003 S. Karger AG, Basel.
引用
收藏
页码:402 / 409
页数:8
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