A niche for adult neural stem cells

被引：491

作者：

Doetsch, F ^{[1
]}

机构：

[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 05期

关键词：

D O I：

10.1016/j.gde.2003.08.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adult mammalian brain harbors multipotent stem cells, which reside and participate in specialized niches that support self-renewal and differentiation. The first cellular and molecular elements of the stem cell niche in the adult brain have been identified and include cell-cell interactions and somatic cell signaling, the vasculature, the extracellular matrix and basal lamina. Furthermore, regulation at the epigenetic level via chromatin modification and remodeling is an integral aspect of stem cell biology. Understanding the in vivo stem cell niche will provide a framework for the elucidation of stem cell function in the adult brain.

引用

页码：543 / 550

页数：8

共 60 条

[1] Regulation of neuronal traits by a novel transcriptional complex [J].

Ballas, N ;

Battaglioli, E ;

Atouf, F ;

Andres, ME ;

Chenoweth, J ;

Anderson, ME ;

Burger, C ;

Moniwa, M ;

Davie, JR ;

Bowers, WJ ;

Federoff, HJ ;

Rose, DW ;

Rosenfeld, MG ;

Brehm, P ;

Mandel, G .

NEURON, 2001, 31 (03) :353-365

[2] Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].

Bergers, G ;

Brekken, R ;

McMahon, G ;

Vu, TH ;

Itoh, T ;

Tamaki, K ;

Tanzawa, K ;

Thorpe, P ;

Itohara, S ;

Werb, Z ;

Hanahan, D .

NATURE CELL BIOLOGY, 2000, 2 (10) :737-744

[3] Functions of cell surface heparan sulfate proteoglycans [J].

Bernfield, M ;

Götte, M ;

Park, PW ;

Reizes, O ;

Fitzgerald, ML ;

Lincecum, J ;

Zako, M .

ANNUAL REVIEW OF BIOCHEMISTRY, 1999, 68 :729-777

[4] Proneural genes and the specification of neural cell types [J].

Bertrand, N ;

Castro, DS ;

Guillemot, F .

NATURE REVIEWS NEUROSCIENCE, 2002, 3 (07) :517-530

[5] LeX/ssea-1 is expressed by adult mouse CNS stem cells, identifying them as nonependymal [J].

Capela, A ;

Temple, S .

NEURON, 2002, 35 (05) :865-875

[6] Regulation of cerebral cortical size by control of cell cycle exit in neural precursors [J].

Chenn, A ;

Walsh, CA .

SCIENCE, 2002, 297 (5580) :365-369

[7]

Chiasson BJ, 1999, J NEUROSCI, V19, P4462

[8]

Chojnacki A, 2003, J NEUROSCI, V23, P1730

[9] Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone [J].

Conover, JC ;

Doetsch, F ;

Garcia-Verdugo, JM ;

Gale, NW ;

Yancopoulos, GD ;

Alvarez-Buylla, A .

NATURE NEUROSCIENCE, 2000, 3 (11) :1091-1097

[10] The expression pattern of the cell cycle inhibitor p19INK4d by progenitor cells of the rat embryonic telencephalon and neonatal anterior subventricular zone [J].

Coskun, V ;

Luskin, MB .

JOURNAL OF NEUROSCIENCE, 2001, 21 (09) :3092-3103

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