Changes in chloride homeostasis-regulating gene expressions in the rat hippocampus following amygdala kindling

被引：32

作者：

Okabe, A

Yokokura, M

Toyoda, H

Shimizu-Okabe, C

Ohno, K

Sato, K

Fukuda, A

机构：

[1] Hamamatsu Univ Sch Med, Dept Physiol, Hamamatsu, Shizuoka 4313192, Japan

[2] Hamamatsu Univ Sch Med, Dept Anat, Hamamatsu, Shizuoka 4313192, Japan

来源：

BRAIN RESEARCH | 2003年 / 990卷 / 1-2期

关键词：

epilepsy; Cl-; channel; cotransporter; GABA; KCC; NKCC;

D O I：

10.1016/S0006-8993(03)03528-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In a rat kindling model, we examined expression patterns of NKCC1, KCC1, KCC2, and CLC-2. In the dentate granule cell layer, there was an activity-dependent increase in NKCC1 mRNA but significant decreases in KCC1 and CLC-2 mRNAs. In addition, CLC-2 mRNA expression was markedly decreased in CA1 pyramidal layer. These results suggest that an increase in [Cl-](i) and a resultant reduction in GABAergic inhibition may occur in hippocampus of epileptic rats. (C) 2003 Elsevier B.V. All rights reserved.

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收藏

页码：221 / 226

页数：6

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