Antisense apolipoprotein B therapy: where do we stand?

被引：30

作者：

Akdim, Fatima ^{[1
]}

Stroes, Erik S. G. ^{[1
]}

Kastelein, John J. P. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1100 Amsterdam, Netherlands

来源：

CURRENT OPINION IN LIPIDOLOGY | 2007年 / 18卷 / 04期

关键词：

antisense; apolipoprotein B; cholesterol; low density lipoprotein; oligonucleotide;

D O I：

10.1097/MOL.0b013e328248b4ad

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

ISIS 301012 has initially shown promising results in experimental animal models, and in clinical trials in humans. Besides the effect of reducing apolipoprotein B-100 and LDL-cholesterol, this compound also significantly lowers plasma triglycerides. Safety concerns related to the drug include increased liver-function tests. To date no evidence of hepatic steatosis has been reported. Nonetheless, clinical trials of longer duration are required to demonstrate further safety.

引用

页码：397 / 400

页数：4

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