Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation

被引：213

作者：

Mancini, SJC

Mantei, N

Dumortier, A

Suter, U

MacDonald, HR

Radtke, F ^{[1
]}

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

[2] Swiss Fed Inst Technol, Inst Cell Biol, Dept Biol, Zurich, Switzerland

来源：

BLOOD | 2005年 / 105卷 / 06期

关键词：

D O I：

10.1182/blood-2004-08-3207

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Jagged1-mediated Notch signaling has been suggested to be critically involved in hematopoietic stem cell (HSC) self-renewal. Unexpectedly, we report here that inducible Cre-loxP-mediated inactivation of the Jagged1 gene in bone marrow progenitors and/or bone marrow (BM) stromal cells does not impair HSC self-renewal or differentiation in all blood lineages. Mice with simultaneous inactivation of Jagged1 and Notch1 in the BM compartment survived normally following a 5FU-based in vivo challenge. In addition, Notch1-deficient HSCs were able to reconstitute mice with inactivated competitive conditions. In contrast to earlier reports, these data exclude an essential role for Jagged1-mediated Notch signaling during hematopoiesis. Jagged1 in the BM stroma even under (c) 2005 by The American Society of Hematology.

引用

页码：2340 / 2342

页数：3

共 19 条

[1] Osteoblastic cells regulate the haematopoietic stem cell niche [J].