Immunopathogenesis and role of T cells in psoriasis

被引：152

作者：

Ghoreschi, Kamran ^{[1
]}

Weigert, Christina ^{[1
]}

Roecken, Martin ^{[1
]}

机构：

[1] Univ Tubingen, Dept Dermatol, D-72076 Tubingen, Germany

来源：

CLINICS IN DERMATOLOGY | 2007年 / 25卷 / 06期

关键词：

D O I：

10.1016/j.clindermatol.2007.08.012

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Psoriasis is a T cell-dependent autoimmune disease of the skin and joints. Disease manifestation is orchestrated by proinflammatory CD4-positive T helper cells producing either interferon-gamma (Th1) or interleukin (IL)-17 (Th17). These Th1 and TH17 cells interact with dermal dendritic cells, macrophages, mast cells, and neutrophils. Together, they cause an inflammation that mainly involves interferon- gamma, tumor necrosis factor, IL-8, IL-12, IL-17, IL-19, and IL-23. New therapeutics either are directed against T cells, tumor necrosis factor, and IL-12/IL-23 or deviate immune responses into a protective IL-4-dominated Th2 phenotype. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：574 / 580

页数：7

共 83 条

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