The toll of too much TLR7

被引：43

作者：

Krieg, Arthur M. ^{[1
]}

机构：

[1] Coll Pharmaceut Grp, Wellesley, MA 02481 USA

来源：

IMMUNITY | 2007年 / 27卷 / 05期

关键词：

D O I：

10.1016/j.immuni.2007.11.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Toll-like receptor 7 (TLR7) detects viral RNA, but can be activated inappropriately by self-RNA, leading to autoimmunity. Deane et al. (2007) show that Tlr7 gene dosage is directly related to the risk of lupus in a mouse model.

引用

页码：695 / 697

页数：3

共 10 条

[1]

Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type IFN [J].

Bekeredjian-Ding, IB ;

Wagner, M ;

Hornung, V ;

Giese, T ;

Schnurr, M ;

Endres, S ;

Hartmann, G .

JOURNAL OF IMMUNOLOGY, 2005, 174 (07) :4043-4050

[2]

TLR7 Ligands induce higher IFN-α production in females [J].

Berghofer, Beate ;

Frommer, Ture ;

Haley, Gabriela ;

Fink, Ludger ;

Bein, Gregor ;

Hackstein, Holger .

JOURNAL OF IMMUNOLOGY, 2006, 177 (04) :2088-2096

[3]

Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice [J].

Berland, Robert ;

Fernandez, Luis ;

Kari, Elina ;

Han, Jin-Hwan ;

Lomakin, Ina ;

Akira, Shizuo ;

Wortis, Henry H. ;

Kearney, John F. ;

Ucci, Angelo A. ;

Imanishi-Kari, Thereza .

IMMUNITY, 2006, 25 (03) :429-440

[4]

Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus [J].

Christensen, Sean R. ;

Shupe, Jonathan ;

Nickerson, Kevin ;

Kashgarian, Michael ;

Flavell, Richard A. ;

Shlomchik, Mark J. .

IMMUNITY, 2006, 25 (03) :417-428

[5]

Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation [J].

Deane, Jonathan A. ;

Pisitkun, Prapaporn ;

Barrett, Rebecca S. ;

Feigenbaum, Lionel ;

Town, Terrence ;

Ward, Jerrold M. ;

Flavell, Richard A. ;

Bolland, Silvia .

IMMUNITY, 2007, 27 (05) :801-810

[6]

Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects [J].

Kelley, James ;

Johnson, Martin R. ;

Alarcon, Graciela S. ;

Kimberly, Robert P. ;

Edberg, Jeffrey C. .

ARTHRITIS AND RHEUMATISM, 2007, 56 (10) :3375-3378

[7]

Toll-like receptors 7, 8, and 9: linking innate immunity to autoimmunity [J].

Krieg, Arthur M. ;

Vollmer, Joerg .

IMMUNOLOGICAL REVIEWS, 2007, 220 :251-269

[8]

Toll-like receptors in systemic autoimmune disease [J].

Marshak-Rothstein, Ann .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (11) :823-835

[9]

Pisitkun P, 2006, SCIENCE, V312, P1669, DOI 10.1126/science.1124978

[10]

A Tlr7 translocation accelerates systemic autoimmunity in murine lupus [J].

Subramanian, Srividya ;

Tus, Katalin ;

Li, Quan-Zhen ;

Wang, Andrew ;

Tian, Xiang-Hong ;

Zhou, Jinchun ;

Liang, Chaoying ;

Bartov, Guy ;

McDaniel, Lisa D. ;

Zhou, Xin J. ;

Schultz, Roger A. ;

Wakeland, Edward K. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (26) :9970-9975

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