Commensal flora and the regulation of inflammatory and autoimmune responses

被引：76

作者：

Kranich, Jan ^{[2
,3
]}

Maslowski, Kendle M. ^{[2
,3
,4
]}

Mackay, Charles R. ^{[1
]}

机构：

[1] Monash Univ, Sch Biomed Sci, Clayton, Vic 3800, Australia

[2] St Vincents Hosp, Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia

[3] Cooperat Res Ctr Asthma & Airways, Glebe, NSW 2037, Australia

[4] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia

来源：

SEMINARS IN IMMUNOLOGY | 2011年 / 23卷 / 02期

关键词：

Gut bacteria; Commensals; Microbiota; Autoimmunity; Symbiosis factors; Dysbiosis; CHAIN FATTY-ACIDS; EARLY RHEUMATOID-ARTHRITIS; GUT MICROBIOTA; INTESTINAL MICROBIOTA; IMMUNE-RESPONSES; EARLY-CHILDHOOD; BACTERIAL-COLONIZATION; ANAEROBIC-BACTERIA; FECAL MICROFLORA; ESCHERICHIA-COLI;

D O I：

10.1016/j.smim.2011.01.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gut microbiota has recently been recognized for its role in immune regulation, and changes in gut microbiota may be the basis for an increased incidence of autoimmune diseases and asthma in developed countries. Beneficial microbes produce factors that are distributed systemically, and therefore can influence peripheral inflammatory responses. Such symbiosis factors are important for the control and resolution of inflammation and autoimmune diseases. Here we discuss immune regulation by recently identified symbiosis factors and how certain environmental factors favor their production and influence the composition of the gut microflora. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：139 / 145

页数：7

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