Linking age-related defects in B lymphopoiesis to the aging of hematopoietic stem cells

被引：35

作者：

Miller, JP ^{[1
]}

Allman, D ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

来源：

SEMINARS IN IMMUNOLOGY | 2005年 / 17卷 / 05期

关键词：

aging; progenitor; transcription factor; differentiation; hematopoietic stem cell;

D O I：

10.1016/j.smim.2005.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cell genesis declines with age, but at what stage and why remains unclear. Previous studies attribute the decline in B cell production in aged mice to both environmental and cell-intrinsic defects that impact mid-to-late stream B cell precursors. However, mounting evidence suggests that the aging process may also negatively affect the earliest phases of B cell development. We review past studies on the B cells and aging question, discuss recent data suggesting that age-associated defects in B cell development reflect deficiencies in hematopoietic stem cell-proximal progenitor pools, and provide an integrative model that will hopefully facilitate further studies into this complex problem. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：321 / 329

页数：9

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