Salt wasting and blood pressure

被引：16

作者：

Devuyst, Olivier ^{[1
]}

机构：

[1] Univ Catholique Louvain, Div Nephrol, Sch Med, B-1200 Brussels, Belgium

来源：

NATURE GENETICS | 2008年 / 40卷 / 05期

关键词：

D O I：

10.1038/ng0508-495

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recessive loss-of-function mutations in genes involved in renal NaCl handling cause rare diseases characterized by salt wasting and reduced blood pressure of variable severity. A new study shows that the carrier state for rare inactivating mutations in three genes involved in NaCl transport in the kidney is associated with a significant blood pressure reduction and a reduced risk of hypertension in the general population.

引用

页码：495 / 496

页数：3

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