OLIG2 as a specific marker of oligodendroglial tumour cells

被引：130

作者：

Marie, Y

Sanson, M

Mokhtari, K

Leuraud, P

Kujas, M

Delattre, JY

Poirier, J

Zalc, B

Khê, HX ^{[1
]}

机构：

[1] Grp Hosp Pitie Salpetriere, Federat Neurol Mazarin, F-75651 Paris 13, France

[2] INSERM, U495, Lab Biol Interact Neurone Glie, Paris, France

[3] UPMC, Paris, France

[4] Grp Hosp Pitie Salpetriere, Lab Histoembryol Cytogenet, F-75634 Paris, France

[5] Grp Hosp Pitie Salpetriere, Lab Neuropathol R Escourolle, F-75634 Paris, France

来源：

LANCET | 2001年 / 358卷 / 9278期

关键词：

D O I：

10.1016/S0140-6736(01)05499-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OLIG2 is a recently Identified transcription factor involved In the specification of cells In the oligodendroglial lineage. We Investigated the expression of OLIG2 by In-situ hybridisation In 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases). OLIG2-positive cells corresponding to neoplastic oligodendrocytes were present in all oligodendrogliomas and oligoastrocytomas. By contrast, OLIG2 expression was not detected in the non-oligodendroglial tumours. Thus, oligodendroglioma probably arise from oligodendrocyte precursor cells. OLIG2 should prove a useful marker for the diagnosis of oligodendroglial tumours.

引用

页码：298 / 300

页数：3

共 6 条

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