Cross-linked enzyme crystals

被引:74
作者
Häring, D [1 ]
Schreier, P [1 ]
机构
[1] Univ Wurzburg, Chair Food Chem, D-97074 Wurzburg, Germany
关键词
D O I
10.1016/S1367-5931(99)80007-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The active site of cross-linked enzyme crystals can be further modified by chemical means, yielding a new type of chemically engineered enzyme. In the past year, the characteristics of crosslinked protein crystals as microporous materials have been studied and used as stationary phases in chromatographic separations.
引用
收藏
页码:35 / 38
页数:4
相关论文
共 33 条
[1]   KINETIC-PROPERTIES OF CARBOXYPEPTIDASE-B IN SOLUTIONS AND CRYSTALS [J].
ALTER, GM ;
LEUSSING, DL ;
NEURATH, H ;
VALLEE, BL .
BIOCHEMISTRY, 1977, 16 (16) :3663-3668
[2]  
Bossard, 1997, German Patent, Patent No. 19715465
[3]   Enzymatic synthesis of nonracemic inherently chiral calix[4]arenes by lipase-catalysed transesterification [J].
Browne, JK ;
McKervey, MA ;
Pitarch, M ;
Russell, JA ;
Millership, JS .
TETRAHEDRON LETTERS, 1998, 39 (13) :1787-1790
[4]   Application of structure-based thermodynamic calculations to the rationalization of the enantioselectivity of subtilisin in organic solvents [J].
Colombo, G ;
Ottolina, G ;
Carrea, G ;
Bernardi, A ;
Scolastico, C .
TETRAHEDRON-ASYMMETRY, 1998, 9 (07) :1205-1214
[5]  
DRAUZ K, 1995, ENZYME CATALYSIS INO
[6]  
Faber K, 1997, BIOTRANSFORMATIONS O, DOI 10.1007/978-3-319-61590-5
[7]   X-RAY CRYSTAL-STRUCTURE OF CROSS-LINKED SUBTILISIN CARLSBERG IN WATER VS ACETONITRILE [J].
FITZPATRICK, PA ;
RINGE, D ;
KLIBANOV, AM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 198 (02) :675-681
[8]   ENZYME CRYSTAL-STRUCTURE IN A NEAT ORGANIC-SOLVENT [J].
FITZPATRICK, PA ;
STEINMETZ, ACU ;
RINGE, D ;
KLIBANOV, AM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (18) :8653-8657
[9]  
Fry AJ, 1997, ELEC SOC S, V97, P115
[10]   ENZYME FUNCTION IN ORGANIC-SOLVENTS [J].
GUPTA, MN .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 203 (1-2) :25-32