A Putative Vesicular Transporter Expressed in Drosophila Mushroom Bodies that Mediates Sexual Behavior May Define a Neurotransmitter System

被引：17

作者：

Brooks, Elizabeth S. ^{[1
,2
]}

Greer, Christina L. ^{[1
,2
]}

Romero-Calderon, Rafael ^{[1
,2
]}

Serway, Christine N. ^{[1
,2
]}

Grygoruk, Anna ^{[1
,2
]}

Haimovitz, Jasmine M. ^{[1
,2
]}

Bac T. Nguyen ^{[1
,2
]}

Najibi, Rod ^{[1
,2
]}

Tabone, Christopher J. ^{[3
]}

de Belle, J. Steven ^{[3
]}

Krantz, David E. ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Biobehav Sci, Hatos Ctr Neuropharmacol,Gonda Goldschmied Ctr Ge, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Jane & Terry Semel Inst Neurosci & Human Behav, Gonda Goldschmied Ctr Genet & Neurosci Res, Los Angeles, CA 90095 USA

[3] Univ Nevada, Sch Life Sci, Las Vegas, NV 89154 USA

来源：

NEURON | 2011年 / 72卷 / 02期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

MONOAMINE TRANSPORTER; SUBSTRATE RECOGNITION; GENETIC DISSECTION; CENTRAL COMPLEX; MOTOR-ACTIVITY; INSECT BRAIN; TAURINE-LIKE; MELANOGASTER; MUTANTS; BODY;

D O I：

10.1016/j.neuron.2011.08.032

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Vesicular transporters are required for the storage of all classical and amino acid neurotransmitters in synaptic vesicles. Some neurons lack known vesicular transporters, suggesting additional neurotransmitter systems remain unidentified. Insect mushroom bodies (MBs) are critical for several behaviors, including learning, but the neurotransmitters released by the intrinsic Kenyon cells (KCs) remain unknown. Likewise, KCs do not express a known vesicular transporter. We report the identification of a novel Drosophila gene portabella (prt) that is structurally similar to known vesicular transporters. Both larval and adult brains express PRT in the KCs of the MBs. Additional PRT cells project to the central complex and optic ganglia. prt mutation causes an olfactory learning deficit and an unusual defect in the male's position during copulation that is rescued by expression in KCs. Because prt is expressed in neurons that lack other known vesicular transporters or neurotransmitters, it may define a previously unknown neurotransmitter system responsible for sexual behavior and a component of olfactory learning.

引用

页码：316 / 329

页数：14

共 72 条

[1]

Species-specific effects of single sensillum ablation on mating position in Drosophila [J].