Lnterferon-γ and atherosclerosis:: Pro- or anti-atherogenic?

被引：101

作者：

Harvey, EJ ^{[1
]}

Ramji, DP ^{[1
]}

机构：

[1] Cardiff Univ, Cardiff Sch Biosci, Cardiff CF10 3US, S Glam, Wales

来源：

CARDIOVASCULAR RESEARCH | 2005年 / 67卷 / 01期

关键词：

atherosclerosis; cytokines; foam cell; inflammation; interferon-gamma;

D O I：

10.1016/j.cardiores.2005.04.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is considered to be a form of chronic inflammation governed by a complex network of inter- and intra-cellular signaling pathways. The pleiotropic cytokine interferon-gamma (IFN-gamma) is a key pro-inflammatory mediator that is expressed at high levels in atherosclerotic lesions. IFN-gamma regulates the function and properties of all the cell types in the vessel wall. The precise role of IFN-gamma in atherogenesis is complex, with both pro- and anti-atherogenic actions being identified. This review will discuss these actions of the cytokine along with recent findings that have emerged from mouse models of atherosclerosis that are deficient in IFN-gamma signaling. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：11 / 20

页数：10

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