Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients

被引:27
作者
Pruneta-Deloche, V [1 ]
Ponsin, G
Groisne, L
Fruchart-Najib, J
Lagarde, M
Moulin, P
机构
[1] INSA, INSERM, UMR 585, Villeurbanne, France
[2] Hop Cardiovasc & Pneumol Louis Pradel, Unite 11, Lyon, France
[3] Inst Pasteur, INSERM, U545, Lille, France
关键词
postprandial lipemia; Type; 2; diabetes; apolipoprotein AV; lipolysis;
D O I
10.1016/j.atherosclerosis.2005.01.034
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Postprandial hypertriglyceridemia is considered as a risk factor for cardiovascular disease in Type 2 diabetes. However, little is known about the underlying mechanisms. Since the recently discovered apolipoprotein (apo) AV was identified as a modulator of triglyceride (TG) metabolism. the aim of the study was to determine the postprandial apoAV profile of Type 2 diabetic patients. We compared data from 11 patients with Type 2 diabetes mellitus to that of 12 non-diabetic normolipidemic subjects following the ingestion of a lipid-rich cream. Postprandial apoAV was elevated in diabetic patients but no correlation was observed either with plasma TG concentration or with the intensity of lipoprotein lipase-dependent lipolysis. These data obtained in human subjects suggest that plasma apoAV concentration does not play an acute or a direct role in the regulation of plasma TG in the postprandial state. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:403 / 405
页数:3
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