A fine-scale map of recombination rates and hotspots across the human genome

被引:804
作者
Myers, S [1 ]
Bottolo, L [1 ]
Freeman, C [1 ]
McVean, G [1 ]
Donnelly, P [1 ]
机构
[1] Univ Oxford, Dept Stat, Oxford OX1 3TG, England
基金
英国惠康基金;
关键词
D O I
10.1126/science.1117196
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Genetic maps, which document the way in which recombination rates vary over a genome, are an essential tool for many genetic analyses. We present a high-resolution genetic map of the human genome, based on statistical analyses of genetic variation data, and identify more than 25,000 recombination hotspots, together with motifs and sequence contexts that play a role in hotspot activity. Differences between the behavior of recombination rates over large (megabase) and small (kilobase) scales lead us to suggest a two-stage model for recombination in which hotspots are stochastic features, within a framework in which large-scale rates are constrained.
引用
收藏
页码:321 / 324
页数:4
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