NMR structural studies of oligosaccharides related to cancer processes

被引：10

作者：

Jimenez-Barbero, J. ^{[1
]}

Diaz, M. D. ^{[1
]}

Nieto, P. M. ^{[2
]}

机构：

[1] CSIC, Ctr Invest Biol, Madrid 28040, Spain

[2] CSIC, Inst Invest Quim, E-41080 Seville, Spain

来源：

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 01期

关键词：

cancer; NMR; glycoconjugates; glycosaminoglycans;

D O I：

10.2174/187152008783330879

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A summary of spectroscopic methods for structural and conformational elucidation of bioactive carbohydrates based on nuclear magnetic resonance (NMR) is described. The formation of carbohydrate-protein complexes is often the initial step of biological responses. Therefore, knowledge about the structural factors that stabilize the complex may be relevant and contribute to predict the structural/conformational requirements of new drugs acting as agonists. Two examples of medical significance in the cancer research field are discussed (1) conformational studies of glycoconjugates related to antitumour vaccines (2) conformational analysis of glycosaminoglycans and the interaction heparin-fibroblast growth factor (FGF).

引用

收藏

页码：52 / 63

页数：12

相关论文

共 153 条

[1] Enzymatic synthesis of complex glycosaminotrioses and study of their molecular recognition by hevein domains [J].

Aboitiz, N ;

Cañada, FJ ;

Husáková, L ;

Kuzma, M ;

Kren, V ;

Jiménez-Barbero, J .

ORGANIC & BIOMOLECULAR CHEMISTRY, 2004, 2 (14) :1987-1994

[2] NMR and modeling studies of protein-carbohydrate interactions:: Synthesis, three-dimensional structure, and recognition properties of a minimum hevein domain with binding affinity for chitooligosaccharides [J].

Aboitiz, N ;

Vila-Perelló, M ;

Groves, P ;

Asensio, JL ;

Andreu, D ;

Cañada, FJ ;

Jiménez-Barbero, J .

CHEMBIOCHEM, 2004, 5 (09) :1245-1255

[3] Pursuit of optimal carbohydrate-based anticancer vaccines:: Preparation of a multiantigenic unimolecular glycopeptide containing the Tn, MBr1, and Lewisy antigens [J].

Allen, JR ;

Harris, CR ;

Danishefsky, SJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (09) :1890-1897

[4]

Allen JR, 2000, CHEM-EUR J, V6, P1366, DOI 10.1002/(SICI)1521-3765(20000417)6:8<1366::AID-CHEM1366>3.3.CO

[5]

2-B

[6] A MOLECULAR MECHANICS FORCE-FIELD (MM3) FOR ALCOHOLS AND ETHERS [J].

ALLINGER, NL ;

RAHMAN, M ;

LII, JH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (23) :8293-8307

[7] Oligosaccharides implicated in recognition are predicted to have relatively ordered structures [J].

Almond, A ;

Petersen, BO ;

Duus, JO .

BIOCHEMISTRY, 2004, 43 (19) :5853-5863

[8] The activation of fibroblast growth factors (FGFs) by glycosaminoglycans:: Influence of the sulfation pattern on the biological activity of FGF-1 [J].

Angulo, J ;

Ojeda, R ;

de Paz, JL ;

Lucas, R ;

Nieto, PM ;

Lozano, RM ;

Redondo-Horcajo, M ;

Giménez-Gallego, G ;

Martín-Lomas, M .

CHEMBIOCHEM, 2004, 5 (01) :55-61

[9] Dynamic properties of biologically active synthetic heparin-like hexasaccharides [J].

Angulo, J ;

Hricovíni, M ;

Gairi, M ;

Guerrini, M ;

de Paz, JL ;

Ojeda, R ;

Martín-Lomas, M ;

Nieto, PM .

GLYCOBIOLOGY, 2005, 15 (10) :1008-1015

[10] A molecular dynamics description of the conformational flexibility of the L-iduronate ring in glycosaminoglycans [J].

Angulo, J ;

Nieto, PM ;

Martín-Lomas, M .

CHEMICAL COMMUNICATIONS, 2003, (13) :1512-1513

← 1 2 3 4 5 6 7 8 9 10 →