Why bother using non-human primate models of cognitive disorders in translational research?

被引：33

作者：

Camus, Sandrine ^{[1
]}

Ko, Wai Kin D. ^{[1
]}

Pioli, Elsa ^{[1
]}

Bezard, Erwan ^{[1
,2
,3
]}

机构：

[1] Motac Neurosci Ltd, Manchester, Lancs, England

[2] Univ Bordeaux 2, Inst Malad Neurodegenerat, UMR 5293, F-33000 Bordeaux, France

[3] CNRS, Inst Malad Neurodegenerat, UMR 5293, F-33000 Bordeaux, France

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2015年 / 124卷

关键词：

Non-human primate; Alzheimer; Parkinson; Depression; Ethology; Cantab; Transgenesis; A(2A) RECEPTOR ANTAGONIST; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; ANIMAL-MODELS; MOUSE MODEL; METHODOLOGICAL QUALITY; MACAQUES PRIMATES; TRANSGENIC MODEL; AMYLOID PLAQUES; BRAIN DISEASES;

D O I：

10.1016/j.nlm.2015.06.012

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp models. In this review, we discuss the importance of nhps in translational research, highlighting the advances in technological/methodological approaches for 'bridging the gap' between preclinical and clinical experiments. In this process, we acknowledge that nhps remain a vital tool for the investigation of complex cognitive functions, given their resemblance to humans in aspects of behaviour, anatomy and physiology. The recent improvements made for a suitable nhp model in cognitive research, including new surrogates of disease and application of innovative methodological approaches, are continuous strides for reaching efficient translation for human benefit. This will ultimately aid the development of innovative treatments against the current and future threat of neurological and psychiatric disorders to the global population. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：123 / 129

页数：7

共 144 条

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