Lipid Metabolism and Toxicity in the Heart

被引：452

作者：

Goldberg, Ira J. ^{[1
]}

Trent, Chad M. ^{[1
]}

Schulze, P. Christian ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, New York, NY 10032 USA

来源：

CELL METABOLISM | 2012年 / 15卷 / 06期

关键词：

HORMONE-SENSITIVE LIPASE; FATTY-ACID OXIDATION; PREVENTS LIPOTOXIC CARDIOMYOPATHY; MYOCARDIAL SUBSTRATE METABOLISM; TRIGLYCERIDE TRANSFER PROTEIN; TYPE-2; DIABETES-MELLITUS; SYNTHASE TRANSGENIC MICE; CARDIAC GENE-EXPRESSION; LIPOPROTEIN-LIPASE; PPAR-ALPHA;

D O I：

10.1016/j.cmet.2012.04.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The heart has both the greatest caloric needs and the most robust oxidation of fatty acids (FAs). Under pathological conditions such as obesity and type 2 diabetes, cardiac uptake and oxidation are not balanced and hearts accumulate lipid potentially leading to cardiac lipotoxicity. We will first review the pathways utilized by the heart to acquire FAs from the circulation and to store triglyceride intracellularly. Then we will describe mouse models in which excess lipid accumulation causes heart dysfunction and experiments performed to alleviate this toxicity. Finally, the known relationships between heart lipid metabolism and dysfunction in humans will be summarized.

引用

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页码：805 / 812

页数：8

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