Preparation of amino acid conjugates of betulinic acid with activity against human melanoma

被引：105

作者：

Jeong, HJ

Chai, HB

Park, SY

Kim, DSHL

机构：

[1] Univ Illinois, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60612 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(99)00165-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Betulinic acid has been coupled with a series of amino acids at C-28 carboxylic acid position and the toxicity of the derivatives has been evaluated against cultured human melanoma (MEL-2) and human epidermoid carcinoma of the mouth (KB) cell lines. A number of amino acid conjugates of betulinic acid showed improved water solubility as well as selective cytotoxicity. This investigation demonstrates that amino acid conjugates of betulinic acid can produce potentially important derivatives, which may be developed as antitumor agents. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1201 / 1204

页数：4

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