Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

被引：46

作者：

Leventhal, L

Mathis, JP

Rossi, GC

Pasternak, GW

Bodnar, RJ

机构：

[1] CUNY Queens Coll, Neuropsychol Doctoral Subprogram, Flushing, NY 11367 USA

[2] Mem Sloan Kettering Canc Ctr, George C Cotzias Lab Neurooncol, New York, NY USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 349卷 / 01期

关键词：

hyperphagia; orphanin FQ nociceptin; ORL1/KOR3; clone;

D O I：

10.1016/S0014-2999(98)00272-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/kappa-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：R1 / R3

页数：3

共 8 条

[1]

Leventhal L, 1997, J PHARMACOL EXP THER, V282, P1402

[2] ISOLATION AND STRUCTURE OF THE ENDOGENOUS AGONIST OF OPIOID RECEPTOR-LIKE ORL(1) RECEPTOR [J].