Glycogen: a Trojan horse for neurons

被引：29

作者：

Magistretti, Pierre J.

Allaman, Igor

机构：

[1] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lab Neuroenerget & Cellular Dynam, CH-1015 Lausanne, Switzerland

[2] Univ Vaudois, Ctr Hosp, Ctr Neurosci Psychiat, Dept Psychiat, Lausanne, Switzerland

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 11期

关键词：

D O I：

10.1038/nn1107-1341

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Neural activity leads to the mobilization of energy from glycogen in astrocytes. A new paper reports that neurons have an ambivalent relationship with glycogen: they can synthesize it themselves, but that synthesis induces apoptosis. Presumably for this reason, neurons normally inhibit glycogen synthesis through two redundant pathways.

引用

页码：1341 / 1342

页数：2

共 15 条

[1]

Allaman I, 2000, GLIA, V30, P382, DOI 10.1002/(SICI)1098-1136(200006)30:4<382::AID-GLIA70>3.0.CO

[2]

2-0

[3]

Energy transfer from astrocytes to axons:: the role of CNS glycogen [J].

Brown, AM ;

Tekkök, SB ;

Ransom, BR .

NEUROCHEMISTRY INTERNATIONAL, 2004, 45 (04) :529-536

[4]

GLYCOGEN IN ASTROCYTES - POSSIBLE FUNCTION AS LACTATE SUPPLY FOR NEIGHBORING CELLS [J].

DRINGEN, R ;

GEBHARDT, R ;

HAMPRECHT, B .

BRAIN RESEARCH, 1993, 623 (02) :208-214

[5]

Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation [J].

Fernández-Sánchez, ME ;

Criado-García, O ;

Heath, KE ;

García-Fojeda, B ;

Medraño-Fernández, I ;

Gomez-Garre, P ;

Sanz, P ;

Serratosa, JM ;

de Córdoba, SR .

HUMAN MOLECULAR GENETICS, 2003, 12 (23) :3161-3171

[6]

Recent advances in the molecular basis of Lafora's progressive myoclonus epilepsy [J].

Ganesh, S ;

Puri, R ;

Singh, S ;

Mittal, S ;

Dubey, D .

JOURNAL OF HUMAN GENETICS, 2006, 51 (01) :1-8

[7]

Insights into Lafora disease: Malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin [J].

Gentry, MS ;

Worby, CA ;

Dixon, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (24) :8501-8506

[8]

LOCALIZATION OF GLYCOGEN-SYNTHASE IN BRAIN [J].

INOUE, N ;

MATSUKADO, Y ;

GOTO, S ;

MIYAMOTO, E .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (02) :400-405

[9]

Neuron-glia metabolic coupling and plasticity [J].

Magistretti, Pierre J. .

JOURNAL OF EXPERIMENTAL BIOLOGY, 2006, 209 (12) :2304-2311

[10]

MAGISTRETTI PJ, 2003, FUNDAMENTAL NEUROSCI

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