Antisense approaches for inhibiting respiratory syncytial virus

被引：31

作者：

Cramer, H ^{[1
]}

机构：

[1] Ridgeway Biosyst Inc, Cleveland, OH 44195 USA

来源：

EXPERT OPINION ON BIOLOGICAL THERAPY | 2005年 / 5卷 / 02期

关键词：

2-5A; 2-5A antisense; antisense; antivirals; aptarner; interferon; oligonucleotide; oligodeoxyribonucleotide; palivizumab; phosphorothioate; ribavirin; RNase L; siRNA;

D O I：

10.1517/14712598.5.2.207

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 [微生物学]; 0836 [生物工程]; 090102 [作物遗传育种]; 100705 [微生物与生化药学];

摘要：

Respiratory syncytial virus (RSV) continues as an emerging infectious disease not only among infants and children, but also for the immune-suppressed, hospitalised and the elderly. To date, ribavirin (Virazole (R), ICN Pharmaceuticals Inc.) remains the only therapeutic agent approved for the treatment of RSV. However, its clinical benefits are small and occur only in a fraction of RSV-infected patients. The prophylactic administration of palivizumab (Synagis (TM), MedImmune, Inc.) is problematic and costly and, therefore, only recommended for use in high-risk infants. Clearly, the need for an effective and safe drug remains high. This review discusses several different antisense approaches and compares them with traditional strategies, such as RSV-targeting antibodies and antivirals, as well as developments in vaccine research.

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页码：207 / 220

页数：14

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