Predicting clinical severity in sickle cell anaemia

被引：206

作者：

Steinberg, MH

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[2] Boston Med Ctr, Ctr Excellence Sickle Cell Dis, Boston, MA USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2005年 / 129卷 / 04期

关键词：

single nucleotide polymorphisms; linkage disequilibrium; genetic association; fetal haemoglobin; sickle cell;

D O I：

10.1111/j.1365-2141.2005.05411.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The ability to predict the phenotype of an individual with sickle cell anaemia would allow a reliable prognosis and could guide therapeutic decision making. Some risk factors for individual disease complications are known but are insufficiently precise to use for prognostic purposes; predicting the global disease severity is not yet possible. Genetic association studies, which attempt to link gene polymorphisms with selected disease subphenotypes, may eventually provide useful methods of foretelling the likelihood of certain complications and allow better individualized treatment.

引用

页码：465 / 481

页数：17

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