Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

被引：333

作者：

Konopleva, Marina Y. ^{[1
]}

Jordan, Craig T.

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2011年 / 29卷 / 05期

关键词：

ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; CHEMOKINE RECEPTOR CXCR4; HEMATOPOIETIC PROGENITOR CELLS; BONE-MARROW MICROENVIRONMENT; ACUTE LYMPHOBLASTIC-LEUKEMIA; ENDOTHELIAL GROWTH-FACTOR; MINIMAL RESIDUAL DISEASE; IN-VIVO; INITIATING CELLS;

D O I：

10.1200/JCO.2010.31.0904

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myelogenous leukemia is propagated by a subpopulation of leukemia stem cells (LSCs). In this article, we review both the intrinsic and extrinsic components that are known to influence the survival of human LSCs. The intrinsic factors encompass regulators of cell cycle and prosurvival pathways (such as nuclear factor kappa B [NF-kappa B], AKT), pathways regulating oxidative stress, and specific molecular components promoting self-renewal. The extrinsic components are generated by the bone marrow microenvironment and include chemokine receptors (CXCR4), adhesion molecules (VLA-4 and CD44), and hypoxia-related proteins. New strategies that exploit potentially unique properties of the LSCs and their microenvironment are discussed. J Clin Oncol 29:591-599. (c) 2011 by American Society of Clinical Oncology

引用

页码：591 / 599

页数：9

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