Promoter proximal pausing and the control of gene expression

被引：56

作者：

Li, Jian ^{[1
]}

Gilmour, David S. ^{[1
]}

机构：

[1] Penn State Univ, Ctr Eukaryot Gene Regulat, Dept Biochem & Mol Biol, University Pk, PA 16802 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2011年 / 21卷 / 02期

基金：

美国国家卫生研究院;

关键词：

RNA-POLYMERASE-II; NEGATIVE ELONGATION-FACTOR; P-TEFB; TRANSCRIPTIONAL ELONGATION; DROSOPHILA-MELANOGASTER; POL-II; PRODUCTIVE ELONGATION; NASCENT RNA; HSP70; GENE; NELF;

D O I：

10.1016/j.gde.2011.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The advent of methods for mapping the location of specific proteins across genomes is substantially enlightening our understanding of gene regulation. One recent discovery is that Pol II is concentrated at the 5' end of thousands of genes in mammalian and Drosophila cells. Before this, much research had focused on understanding how sequence-specific, DNA-binding proteins orchestrate the actions of regulators of chromatin structure and the general transcriptional machinery to control transcription initiation. The concentration of Pol II at the 5' ends of genes indicates that key steps regulating transcriptior occur after Pol II has associated with a gene's promoter.

引用

页码：231 / 235

页数：5

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