Antiviral immunity directed by small RNAs

被引：1145

作者：

Ding, Shou-Wei

Voinnet, Olivier ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Plant Pathol & Microbiol, Riverside, CA 92521 USA

[2] Univ Strasbourg, CNRS, Inst Biol Mol Plantes, F-67084 Strasbourg, France

来源：

CELL | 2007年 / 130卷 / 03期

关键词：

D O I：

10.1016/j.cell.2007.07.039

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Plants and invertebrates can protect themselves from viral infection through RNA silencing. This antiviral immunity involves production of virus-derived small interfering RNAs (viRNAs) and results in specific silencing of viruses by viRNA-guided effector complexes. The proteins required for viRNA production as well as several key downstream components of the antiviral immunity pathway have been identified in plants, flies, and worms. Meanwhile, viral mechanisms to suppress this small RNA-directed immunity by viruses are being elucidated, thereby illuminating an ongoing molecular arms race that likely impacts the evolution of both viral and host genomes.

引用

收藏

页码：413 / 426

页数：14

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