A cultural renaissance: in vitro cell biology embraces three-dimensional context

被引：66

作者：

Edelman, DB ^{[1
]}

Keefer, EW ^{[1
]}

机构：

[1] Inst Neurosci, San Diego, CA 92121 USA

来源：

EXPERIMENTAL NEUROLOGY | 2005年 / 192卷 / 01期

关键词：

D O I：

10.1016/j.expneurol.2004.10.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Increasingly, researchers are recognizing the limitations of two-dimensional (2-D), monolayer cell culture and embracing more realistic three-dimensional (3-D) cell culture systems. Currently, 3-D culture techniques are being employed by neuroscientists to grow cells from the central nervous system. From this work, it has become clear that 3-D cell culture offers a more realistic milieu in which the functional properties of neurons can be observed and manipulated in a manner that is not possible in vivo. The implications of this technical renaissance in cell culture for both clinical and basic neuroscience are significant and far-reaching. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1 / 6

页数：6

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