Rapid aldosterone actions: from the membrane to signaling cascades to gene transcription and physiological effects

被引:38
作者
Boldyreff, B [1 ]
Wehling, M [1 ]
机构
[1] Heidelberg Univ, Fac Clin Med Mannheim, Dept Clin Pharmacol, D-68167 Mannheim, Germany
关键词
aldosterone; signaling; rapid actions; membrane receptor; mineralocorticoid receptor; MAPK;
D O I
10.1016/S0960-0760(03)00202-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Nongenomic actions of aldosterone have been described in a number of cell culture and in vivo systems. They occur, in contrast to the classical genomic effects on gene transcription, rapidly within seconds to minutes after aldosterone administration. The primary effector is still unknown. Whether it is a so far unidentified membrane bound aldosterone receptor or the classical mineralocorticoid receptor or both is under debate. The downstream signaling cascade involved in such rapid actions begins to be elucidated. In this work, we discuss the nature of the putative membrane receptor for aldosterone and summarize observed rapid aldosterone effects in different in vitro and in vivo systems. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:375 / 381
页数:7
相关论文
共 68 条
  • [1] Role of 11β-hydroxysteroid dehydrogenase in nongenomic aldosterone effects in human arteries
    Alzamora, R
    Michea, L
    Marusic, ET
    [J]. HYPERTENSION, 2000, 35 (05) : 1099 - 1104
  • [2] CHARACTERIZATION OF ALDOSTERONE BINDING-SITES IN CIRCULATING HUMAN MONONUCLEAR LEUKOCYTES
    ARMANINI, D
    STRASSER, T
    WEBER, PC
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (03): : E388 - E390
  • [3] The classical progesterone receptor associates with p42 MAPK and is involved in phosphatidylinositol 3-kinase signaling in Xenopus oocytes
    Bagowski, CP
    Myers, JW
    Ferrell, JE
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (40) : 37708 - 37714
  • [4] Mineralocorticoid receptor knockout mice:: Pathophysiology of Na+ metabolism
    Berger, S
    Bleich, M
    Schmid, W
    Cole, TJ
    Peters, J
    Watanabe, H
    Kriz, W
    Warth, R
    Greger, R
    Schütz, G
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (16) : 9424 - 9429
  • [5] Phosphoinositide 3-kinase is required for aldosterone-regulated sodium reabsorption
    Blazer-Yost, BL
    Paunescu, TG
    Helman, SI
    Lee, KD
    Vlahos, CJ
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1999, 277 (03): : C531 - C536
  • [6] Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases
    Boonyaratanakornkit, V
    Scott, MP
    Ribon, V
    Sherman, L
    Anderson, SM
    Maller, JL
    Miller, WT
    Edwards, DP
    [J]. MOLECULAR CELL, 2001, 8 (02) : 269 - 280
  • [7] Nongenomic action of 1α,25(OH)2-vitamin D3 -: Activation of muscle cell PLCγ through the tyrosine kinase c-Src and PtdIns 3-kinase
    Buitrago, C
    Pardo, VG
    de Boland, AR
    [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 2002, 269 (10): : 2506 - 2515
  • [8] Buitrago C, 2000, J CELL BIOCHEM, V79, P274, DOI 10.1002/1097-4644(20001101)79:2<274::AID-JCB100>3.0.CO
  • [9] 2-R
  • [10] Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1
    Chang, SS
    Grunder, S
    Hanukoglu, A
    Rosler, A
    Mathew, PM
    Hanukoglu, I
    Schild, L
    Lu, Y
    Shimkets, RA
    NelsonWilliams, C
    Rossier, BC
    Lifton, RP
    [J]. NATURE GENETICS, 1996, 12 (03) : 248 - 253