Genes that regulate metastasis and angiogenesis

被引：47

作者：

Webb, CP ^{[1
]}

Woude, GFV ^{[1
]}

机构：

[1] Van Andel Res Inst, Grand Rapids, MI 49503 USA

来源：

JOURNAL OF NEURO-ONCOLOGY | 2000年 / 50卷 / 1-2期

关键词：

genes; angiogenesis; metastasis; therapy;

D O I：

10.1023/A:1006466605356

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic instability and an accumulation of genetic and epigenetic changes during tumor progression lead to an increasingly aggressive and treatment-resistant phenotype, and ultimately metastasis. In recent years it has become well established that angiogenesis, the process by which new vasculature is formed from pre-existing vessels, is an essential component to primary tumor growth and distant metastasis. A greater understanding of the complex multitude of factors involved in tumor angiogenesis and metastasis is fundamental to the development of potential therapeutics to treat malignant disease. As highlighted throughout this review, angiogenesis and metastasis share many common cellular and molecular features. We will briefly discuss the pertinent genes involved in the regulation of angiogenesis and metastasis.

引用

页码：71 / 87

页数：17

共 210 条

[1] Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells [J].