Multiple single-nucleotide polymorphisms (SNPs) in the Japanese population in six candidate genes for long QT syndrome

被引：17

作者：

Iwasa, H

Kurabayashi, M

Nagai, R

Nakamura, Y

Tanaka, T

机构：

[1] Univ Tokyo, Inst Med Sci, Ctr Human Genome, Lab Mol Med,Minato Ku, Tokyo 1088639, Japan

[2] Gunma Univ, Sch Med, Dept Internal Med 2, Gunma, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Internal Med 2, Tokyo, Japan

[4] Univ Tokyo, Grad Sch Med, Dept Cardiovasc Med, Tokyo, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2001年 / 46卷 / 03期

关键词：

long QT syndrome; single-nucleotide polymorphism; Japanese population; cardiac potassium channel; beta 1-adrenergic receptor; vesicular monoamine transporter;

D O I：

10.1007/s100380170106

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report here 20 single-nucleotide polymorphisms (SNPs), including 15 novel ones, in six genes that are considered to be candidates for long QT syndrome (LQTS): 2 SNPs in KCNB1, 3 in KCND3, 3 in KCNJ11, 7 in ABCC9, 3 in ADRB1, and 2 in SLC18A2. We also examined their allelic frequencies in a Japanese sample population of LQTS-affected and nonaffected individuals. These data will be useful for genetic association studies designed to investigate acquired arrhythmias.

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收藏

页码：158 / 162

页数：5

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