Involvement of GABAA-receptors in the neuroprotective effect of theanine on focal cerebral ischemia in mice

被引：61

作者：

Egashira, Nobuaki

Hayakawa, Kazuhide

Osajima, Megurni

Mishima, Kenichi

Iwasaki, Katsunori

Oishi, Ryozo

Fujiwara, Michihiro ^{[1
]}

机构：

[1] Fukuoka Univ, Fac Pharmaceut Sci, Dept Neuropharmacol, Fukuoka 8140180, Japan

[2] Kyushu Univ Hosp, Dept Pharm, Fukuoka 8128582, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2007年 / 105卷 / 02期

关键词：

theanine; focal cerebral ischemia; gamma-aminobutyric acid(A) (GABA(A)) receptor;

D O I：

10.1254/jphs.SCZ070901

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We investigated the involvement of gamma-aminobutyric acid(A) (GABA(A)) receptors in the neuroprotective effect of gamma-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABA(A)-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABA(A) receptors.

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页码：211 / 214

页数：4

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