Transient lower esophageal sphincter relaxations and gastroesophageal reflux episodes in healthy subjects and GERD patients during 24 hours

被引:25
作者
Grossi, L
Ciccaglione, AF
Travaglini, N
Marzio, L
机构
[1] G d Annunzio Univ, Sch Gastroenterol, Pierangeli Clin, I-65124 Pescara, Italy
[2] Univ G dAnnunzio, Sch Gastroenterol, Gastroenterol Unit, Pescara, Italy
关键词
gastroesophageal reflux disease; manometry; motility; transient lower esophageal sphincter relaxation;
D O I
10.1023/A:1010708602777
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Still little is known about the 24-hr pattern of transient lower esophageal sphincter relaxations (TLESRs), particularly in patients with GERD, The aim of our study was to evaluate the 24-hr esophageal and LES motor pattern and esophageal pH and to identify the relationship between TLESRs and gastroesophageal reflux in healthy subjects and in GERD patients. Ten healthy subjects and nine patients with esophagitis (grade I-II) underwent a 24-hr pH manometric recording by means of a portable electronic device. The recording aimed at identifying the temporal relationships between reflux episodes and LES motor events. The GERD patients showed a greater number of either reflux episodes or TLESRs during the 24 hr as compared to controls. While most refluxes occurred during TLESRs in both groups, a small percentage of TLESRs was followed by reflux episodes in healthy people, with only a slight increase in GERD patients. In conclusion, although representing an important motor pattern during gastroesophageal reflux both in healthy subjects and in patients with GERD, TLESR could probably be considered one of the pathophysiologic mechanisms of gastroesophageal reflux more than the primary cause of reflux episodes.
引用
收藏
页码:815 / 821
页数:7
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