Interstitial insertion of AF10 into the ALL1 gene in a case of infant acute lymphoblastic leukemia

被引：15

作者：

Angioni, A

La Starza, R

Mecucci, C

Sprovieri, T

Matteucci, C

De Rossi, G

Balloni, P

Cimino, G

机构：

[1] Osped Pediat Bambino Gesu, Serv Immunoematol, Rome, Italy

[2] Osped Pediat Bambino Gesu, Dipartimento Ematol, Rome, Italy

[3] Univ Perugia, Ematol & Immunol Clin, I-06100 Perugia, Italy

[4] Univ La Sapienza, Dipartimento Biotechnol Cellulari & Ematol, Rome, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 107卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(98)00105-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The ALL1 gene at 11q23 is a promiscuous gene participating in chromosomal abnormalities of acute leukemias with 1 of over 30 potential partner genes. Among these, the AF10 gene at band 10p12 has been recently cloned and characterized. Acute leukemias with the ALL1/AF10 chimeric gene frequently show heterogeneity in the breakpoints on 10p, as well as complex insertion (10;11) as a result of complex molecular mechanisms leading to the ALL1/AF10 fusion. In this context, we report the first description of an infant acute lymphoblastic leukemia with an interstitial insertion of the AF10 gene into the 11q23 band, resulting in the transcription of the ALL1/AF10 fusion product. Furthermore, rye show how different diagnostic tools such as molecular cytogenetic, and fluorescence in situ hybridization (FISH) analyses should be combined to resolve complex situations in the 11q23 setting. (C) Elsevier Science Inc., 1998.

引用

页码：107 / 110

页数：4

共 18 条

[1] THE MORPHOLOGICAL CLASSIFICATION OF ACUTE LYMPHOBLASTIC-LEUKEMIA - CONCORDANCE AMONG OBSERVERS AND CLINICAL CORRELATIONS [J].