Microtubule-associated protein 2 (MAP2) expression during synaptic plasticity in the guinea pig cochlea

被引：9

作者：

Ladrech, S

Lenoir, M

Ruel, J

Puel, JL

机构：

[1] INSERM, U583, F-34090 Montpellier, France

[2] Univ Montpellier 1, F-34090 Montpellier, France

[3] Univ Montpellier 2, F-34090 Montpellier, France

来源：

HEARING RESEARCH | 2003年 / 186卷 / 1-2期

关键词：

cochlea; auditory neuron; alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid; regeneration; excitotoxicity;

D O I：

10.1016/S0378-5955(03)00302-2

中图分类号：

R36 [病理学]; R76 [耳鼻咽喉科学];

学科分类号：

100104 ; 100213 ;

摘要：

The expression of different isoforms of microtubule-associated proteins 2 (MAP2), including the low molecular weight form MAP2c present mainly in developing neurons, was investigated in the primary auditory neurons after alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) perfusion in the guinea pig cochlea. MAP2 expression appeared to be tightly regulated in the repairing neurons. Neurite regrowth seems to involve the MAP2c isoform. In cochlear neurons, mechanisms involved in the period of development might be reactivated after excitotoxic injury in the mature cochlea. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：85 / 90

页数：6

共 18 条

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