Fermentable property of dietary fiber may not determine cecal and colonic mucosal growth in fiber-fed rats

被引:20
作者
Hara, H
Suzuki, K
Kobayashi, S
Kasai, T
机构
[1] Dept. of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University
[2] Dept. of Bioscience and Chemistry, Faculty of Agriculture, Hokkaido University, Sapporo 060, Kita-9, Nishi-9, Kita-ku
关键词
dietary fiber; large intestine; mucosa; rats;
D O I
10.1016/S0955-2863(96)00105-2
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Differences in cecal and colonic mucosal weight, DNA, RNA, and protein content were observed after feeding fiber-free or cellulose, sugar-beet fiber (SBF), psyllium- and guar gum-containing diets in Sprague-Dawley male rats in regard to fermentable and physical properties of the dietary fiber. In mts Sed a low fermentable viscous fiber, psyllium, protein, RNA, and DNA contents in the cecal mucosa were greater than those in the fiber-free and two insoluble fiber groups. The effects of psyllium-feeding on the colonic mucosa were much greater than those of the other groups, except RNA and DNA content in the SBF group. In mts fed a highly fermentable viscous polysaccharide, guar gum, changes in the cecal protein, RNA and DNA content were very similar to those in the psyllium group. In contrast, guar grim Seeding did not influence any indications of the colonic mucosa. The ingestion of cellulose did not affect the cecal and colonic mucosa. Effects of a highly fermentable insoluble fiber, SBF, on the cecal mucosa were intermediate between cellulose and soluble fiber groups. Colonic DNA pool in the SBF group was high and comparable to that in the psyllium group. The present study shows that fermentable property is not sole determinant of the mucosal growth of the large intestine by dietary fiber, and the effects of physical stress by dietary fiber on the cecal and colonic mucosa may be greater than stimulation of fermented products. (C) Elsevier Science Inc. 1996
引用
收藏
页码:549 / 554
页数:6
相关论文
共 27 条
[1]   POTENTIAL SYNERGISM BETWEEN WHEAT BRAN AND PSYLLIUM - ENHANCED INHIBITION OF COLON-CANCER [J].
ALABASTER, O ;
TANG, ZC ;
FROST, A ;
SHIVAPURKAR, N .
CANCER LETTERS, 1993, 75 (01) :53-58
[2]  
ARITSUKA T, 1989, NIPPON NOGEIK KAISHI, V63, P1221
[3]  
Aritsuka T., 1989, Nippon Eiyo Shokuryo Gakkaishi = Journal of the Japanese Society of Nutrition and Food Science, V42, P295
[4]   ASSAY FOR NANOGRAM QUANTITIES OF DNA IN CELLULAR HOMOGENATES [J].
BRUNK, CF ;
JONES, KC ;
JAMES, TW .
ANALYTICAL BIOCHEMISTRY, 1979, 92 (02) :497-500
[5]   CECAL AND FECAL SHORT-CHAIN FATTY-ACIDS AND STOOL OUTPUT IN RATS FED ON DIETS CONTAINING NONSTARCH POLYSACCHARIDES [J].
EDWARDS, CA ;
EASTWOOD, MA .
BRITISH JOURNAL OF NUTRITION, 1995, 73 (05) :773-781
[6]  
FLECK A, 1962, BIOCHIM BIOPHYS ACTA, V55, P571
[7]  
FLINO M, 1995, J NUTR, V125, P1521
[8]   EVALUATION OF FERMENTABILITY OF ACID-TREATED MAIZE HUSK BY RAT CECAL BACTERIA IN-VIVO AND IN-VITRO [J].
HARA, H ;
SAITO, Y ;
NAKASHIMA, H ;
KIRIYAMA, S .
BRITISH JOURNAL OF NUTRITION, 1994, 71 (05) :719-729
[10]  
HEERDT BG, 1994, CANCER RES, V54, P3228