Radiosynthesis of carbon-11-labeled camptothecin derivatives as potential positron emission tomography tracers for imaging of topoisomerase I in cancers

被引：17

作者：

Gao, MZ

Miller, KD

Sledge, GW

Zheng, QH ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期

关键词：

carbon-1-labeled camptothecin derivatives; radiosynthesis; positron emission tomography; tracer; topoisomerase I; cancer;

D O I：

10.1016/j.bmcl.2005.05.108

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four carbon-11-labeled camptothecin derivatives, 9-[C-11]methoxy-20(S)-camptothecin ([C-11]5), 10-[C-11]methoxy-20(S)-camptothecin ([C-11]7), 9-nitro-10-[C-11]methoxy-20(S)-camptothecin ([C-11]9), and 9-[([C-11]trimethylamino)methyl]-10-hydroxy-20(S)-camptothecin ([C-11]11), have been synthesized as potential positron emission tomography tracers for imaging of topoisomerase I in cancers. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：3865 / 3869

页数：5

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