Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group gene

被引：97

作者：

Kimura, M

Koseki, Y

Yamashita, M

Watanabe, N

Shimizu, C

Katsumoto, T

Kitamura, T

Taniguchi, M

Koseki, H

Nakayama, T

机构：

[1] Chiba Univ, Grad Sch Med, Dept Med Immunol, Chiba, Japan

[2] Chiba Univ, Grad Sch Med, Dept Mol Immunol, Chiba, Japan

[3] Chiba Univ, Grad Sch Med, Dept Mol Embryol, Chiba, Japan

[4] Univ Tokyo, Inst Med Sci, Dept Hematopoiet Factors, Tokyo, Japan

来源：

IMMUNITY | 2001年 / 15卷 / 02期

关键词：

D O I：

10.1016/S1074-7613(01)00182-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polycomb group (PcG) gene products regulate homeobox gene expression in Drosophila and vertebrates and also cell cycle progression of immature lymphocytes. In a gene-disrupted mouse for polycomb group gene mel-18, mature peripheral T cells exhibited normal anti-TCR-induced proliferation; however, the production of Th2 cytokines (IL-4, IL-5, and IL-13) was significantly reduced, whereas production of IFN gamma was modestly enhanced. Th2 cell differentiation was impaired, and the defect was associated with decreased levels in demethylation of the IL-4 gene. Significantly, reduced GATA3 induction was demonstrated. In vivo antigen-induced IgG1 production and Nippostrongylus brasiliensis-induced eosinophilia were significantly affected, reflecting the deficit in Th2 cell differentiation. Thus, the PcG gene products play a critical role in the control of Th2 cell differentiation and Th2-dependent immune responses.

引用

页码：275 / 287

页数：13

共 68 条

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