A review of Parkinson's disease

被引:553
作者
Davie, C. A. [1 ]
机构
[1] Royal Free Hosp NHS Trust, London NW3 2QG, England
关键词
Parkinson's disease; motor complications; non-motor complications;
D O I
10.1093/bmb/ldn013
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction: Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Sources of data: Literature search using Medline with keywords Parkinson's disease supplemented with previously published papers known to the author. Areas of agreement: There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to the more commonly recognized motor complications. Areas of controversy: Although there is growing circumstantial evidence, it remains to be proven whether any of the current treatments for PD have a neuroprotective effect. Areas timely for developing research: Although there is no cure, there are several management options for the early treatment of PD. As the disease progresses, further treatment options are available; however, the management of late-stage motor complications and non-motor symptoms remains particularly challenging and will benefit from further clinical research.
引用
收藏
页码:109 / 127
页数:19
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