Parkinson's disease;
motor complications;
non-motor complications;
D O I:
10.1093/bmb/ldn013
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Introduction: Parkinson's disease (PD) is one of the most common neurodegenerative disorders. Sources of data: Literature search using Medline with keywords Parkinson's disease supplemented with previously published papers known to the author. Areas of agreement: There have been significant recent advances in the understanding of the pathogenesis of the disease. There has also been a greater realization that the disorder may be associated with significant non-motor disturbances in addition to the more commonly recognized motor complications. Areas of controversy: Although there is growing circumstantial evidence, it remains to be proven whether any of the current treatments for PD have a neuroprotective effect. Areas timely for developing research: Although there is no cure, there are several management options for the early treatment of PD. As the disease progresses, further treatment options are available; however, the management of late-stage motor complications and non-motor symptoms remains particularly challenging and will benefit from further clinical research.