Regulation of TNFR1 and CD95 signalling by receptor compartmentalization

被引：225

作者：

Schuetze, Stefan ^{[1
]}

Tchikov, Vladimir ^{[1
]}

Schneider-Brachert, Wulf ^{[2
]}

机构：

[1] Univ Hosp Schleswig Holstein, Inst Immunol, D-24105 Kiel, Germany

[2] Univ Regensburg, Inst Med Microbiol & Hyg, D-93053 Regensburg, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2008年 / 9卷 / 08期

关键词：

D O I：

10.1038/nrm2430

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The death receptors tumour-necrosis factor receptor-1 (TNFR1) and CD95 (also known as FAS and APO-1) transduce signals that promote cell death by apoptosis. However, these receptors are also capable of inducing anti-apoptotic signals through the activation of the transcription factor nuclear factor-kappa B (NF-kappa B) or through activation of the proliferative mitogen-activated protein kinase (MAPK) cascade. Recent findings reveal a role for receptor internalization and endosomal trafficking in selectively transmitting the signals that lead either to apoptosis or to the survival of the cell.

引用

页码：655 / U5

页数：8

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