Generalized pustulous psoriasis:: A novel extraintestinal manifestation of Crohn's disease?

被引：3

作者：

Canbay, A

Rünzi, M

Gieseler, R

Alamouti, D

Von Kobyletzki, G

Stücker, M

Goebell, H

Altmeyer, P

机构：

[1] Univ Klinikum Essen, Gastroenterol & Hepatol Abt, Med Klin, D-45122 Essen, Germany

[2] Univ Klinikum Essen, Abt Endokrinol, D-45122 Essen, Germany

[3] Ruhr Univ Bochum, Dermatol Klin, D-4630 Bochum, Germany

来源：

ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2001年 / 39卷 / 09期

关键词：

cytokines; chemokines; cellular immunity; inflammation; Th1; TNF-alpha; cA2;

D O I：

10.1055/s-2001-17191

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 66-year-old female patient suffering for 10 years from Crohn's disease firstly presented with a parallel outbreak of generalized pustulous psoriasis and Crohn's disease. A second synchronous exacerbation of both disorders occurred after discontinuation of treatment with prednisolone, methotrexate, and mesalazine. As to their pathogenetic concepts, both disease entities reveal similar immunologic alterations, i.e. comparable patterns of cytokines, chemokines, and inflammatory cells (T cells and neutrophils). Generalized pustulous psoriasis, therefore, might develop as hitherto undescribed, more rare extraintestinal manifestation of Crohn's disease.

引用

页码：801 / +

页数：4

共 23 条

[1]

IL-10 is a key cytokine in psoriasis -: Proof of principle by IL-10 therapy:: A new therapeutic approach [J].