Stem cells feel the difference

被引：74

作者：

Buxboim, Amnon ^{[1
]}

Discher, Dennis E. ^{[1
]}

机构：

[1] Univ Penn, Philadelphia, PA 19104 USA

来源：

NATURE METHODS | 2010年 / 7卷 / 09期

关键词：

FORCES;

D O I：

10.1038/nmeth0910-695

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Arrays of microposts of different heights generate substrates with different flexibility, on which cells can be grown.

引用

页码：695 / 697

页数：3

共 10 条

[1] Growth Factors, Matrices, and Forces Combine and Control Stem Cells [J].

Discher, Dennis E. ;

Mooney, David J. ;

Zandstra, Peter W. .

SCIENCE, 2009, 324 (5935) :1673-1677

[2] Substrate compliance versus ligand density in cell on gel responses [J].

Engler, A ;

Bacakova, L ;

Newman, C ;

Hategan, A ;

Griffin, M ;

Discher, D .

BIOPHYSICAL JOURNAL, 2004, 86 (01) :617-628

[3] Matrix elasticity directs stem cell lineage specification [J].

Engler, Adam J. ;

Sen, Shamik ;

Sweeney, H. Lee ;

Discher, Dennis E. .

CELL, 2006, 126 (04) :677-689

[4] Mechanical regulation of cell function with geometrically modulated elastomeric substrates [J].

Fu, Jianping ;

Wang, Yang-Kao ;

Yang, Michael T. ;

Desai, Ravi A. ;

Yu, Xiang ;

Liu, Zhijun ;

Chen, Christopher S. .

NATURE METHODS, 2010, 7 (09) :733-U95

[5] FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness [J].

Kong, HJ ;

Polte, TR ;

Alsberg, E ;

Mooney, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (12) :4300-4305

[6] Cell locomotion and focal adhesions are regulated by substrate flexibility [J].

Pelham, RJ ;

Wang, YL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (25) :13661-13665

[7] Is the mechanical activity of epithelial cells controlled by deformations or forces? [J].

Saez, A ;

Buguin, A ;

Silberzan, P ;

Ladoux, B .

BIOPHYSICAL JOURNAL, 2005, 89 (06) :L52-L54

[8] Substrate Modulus Directs Neural Stem Cell Behavior [J].

Saha, Krishanu ;

Keung, Albert J. ;

Irwin, Elizabeth F. ;

Li, Yang ;

Little, Lauren ;

Schaffer, David V. ;

Healy, Kevin E. .

BIOPHYSICAL JOURNAL, 2008, 95 (09) :4426-4438

[9] Soft substrates drive optimal differentiation of human healthy and dystrophic myotubes [J].

Serena, Elena ;

Zatti, Susi ;

Reghelin, Elena ;

Pasut, Alessandra ;

Cimetta, Elisa ;

Elvassore, Nicola .

INTEGRATIVE BIOLOGY, 2010, 2 (04) :193-201

[10] Optimal matrix rigidity for stress-fibre polarization in stem cells [J].

Zemel, A. ;

Rehfeldt, F. ;

Brown, A. E. X. ;

Discher, D. E. ;

Safran, S. A. .

NATURE PHYSICS, 2010, 6 (06) :468-473

← 1 →